WOMEN'S HEALTH: ESTROGEN, PROGESTINS AND BLOOD PRESSURE.

R.M.Korth. Research in General Medicine Fida, Munich, Germany.

Aim: A hypertensive risk was invented here with women during pregnancy, intolerance to glucose (IGTT:www.fidabus.com) or with hormone users or with non-pregnant women at metabolic risk beyond hormone use (out of 231).

Methods: Initial biomarkers were anonymously enrolled and oral glucose tolerance was tested (1h-50g-oGTT Reflotron Roche, R.M.Korth, jmhg 3, 279-289, 2006).

Results: First, pregnant women with reversible IGTT had values between 140-169 mg/dl glucose (16% out of 180, aged 31±5 years) having initially normal weight (23±4 kg/m²) reporting healthy food and lifestyle. Normal blood pressure was observed (week 22±2: 104±13/64±11 mmHg; week 38±2: 110±8/73±5 mmHg, ±1S.D.). Pregnant women with persisting control-IGTT tended to gestation diabetes elsewhere (4% ≥170 mg/dl, 1-h-100g glucose). Second, oral contraceptives were not correlated with raised blood pressure (p>0.1) probably as weight and lipids were normal (49 out of 231, 22±4 kg/m², aged 27±7 years, 117±13/82±9 mmHg, LDL: 127±36, HDL: 66±14 mg/dl). Third, aging women with menopausal HRT-hormones (15 out of 46, aged 51±9 years, 25±5 kg/m²) were compared to those without HRT and led away from raised blood pressure (p>0.35). Overall, non-pregnant women with IGTT and mixed hyperlipidemia showed hypertension (14 out of 231 (6%), aged 32±10 years, 26±6 kg/m², LDL: 167±65, HDL: 54±9,Trig:254±73 mg/dl, 136±25/97±12 mmHg). Indeed, women with IGTT or mixed hyperlipidemia had significantly higher blood pressure than appropriate controls (p<0.003) and multivariate analysis provided evidence for direct risk of diastolic hypertension (p<0.05).

Conclusion: This model is suitable to adress hormonal compositions without hypertension as only participants with IGTT-hyperinsulinemia and/or mixed hyperlipidemia were at direct risk for diastolic hypertension.

Accepted Abstract at the 78th European Atherosclerosis Society Congress (A226-0001-00316, EAS 2010 in Hamburg, Germany).