INTOLERANCE TO GLUCOSE DURING PREGNANCY


Dr. Ruth-Maria Korth, Research in General Medicine FIDA, www.fidabus.com, Dr. Harald Korth, Frauenarzt, Baaderstr 80, D-80469, Munich, Germany.

The metabolism of glucose changes during pregnancy (R.-M. Korth, J. Submicrosc. Cytol. Pathol. 32, p. 434, 2000). We investigated the tolerance to glucose (GTT) of 180 pregnant women in their pregnancy week 232 after 50 g oral glucose (1h). The cases of pregnant women with intolerance to glucose increased here in our second five-year-study from 14% (Figur 1: 1995-1999) to 20% (Table 1: 2000-2004). The blood pressure of pregnant women remained normal as compared to nonpregnant women with intolerance to glucose who showed overweight with elevated blood pressure (4% from n=146, 20760 mg/dl, BMI: 287kg/m2, 13733/9617 mmHg, 3511 years. 1 S.D.).
The pregnant women of the second five-years-study showed normal capillary glucose 1 h after 50 g glucose (80%: 11315 mg/dl) or intolerance to glucose (20%: 15516 mg/dl, Tables 1+2). By preference women with intolerance to glucose tests obtained medical counseling for better food and exercising. The fasting blood glucose of these women remained normal and also the HBA1c (<110 mg/dl, HBA1c <6%). The intolerance to glucose could be antagonized by healthy food and exercising within 4 weeks (1h, 100 g, Table 2) despite one pregnant women who developed an insulin-dependent gestation diabetes. One child showed low birth weight and another child was not healthy. All other women remained healthy and their newborn children had normal birth weight (Tables 1+2).


     
Table 1: Intolerance to glucose during pregnancy (2000-2004, n=180, weeks 232):
1st GTT:
1995-1999:
2000-2004:
1st GTT, mg/dl:
Age, years:
weight, kg:
RR, systolic mmHg:
RR, diastolic mmHg:
Birth weight, g:
  <100 mg/dl
21%
16%
902
305
6810
1157
717
3515567
  >=140-
7.5%
7.7%
1422
31 5
718
13213
8311
3128870
  150-
3.5%
4.4%
1553
345
736
1065
7110
3492243
  160-
1.5%
3.8%
1623
337
7011
11413
7113
3071226
  170-

1.7%
1764
322
779
12315
8313
3255360

1,5%
180-

2.2%
23444
356
6813
1056
759
3350156

Table 2: Intolerance to glucose during pregnancy was antagonized by healthy food and exercising after 4 weeks:
2nd GTT:
Control GTT, mg/dl:
Fasting glucose, mg/dl:
Gestation diabetes, cases:
Birth weight, g:
  >=140- 169 mg/dl
12924
6711
Non
3309574
  >=170 mg/dl
14920
828
1
3303233